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CASP-050B
Ac-DEVD-CHO
Ac-Asp-Glu-Val-Asp-CHO
Size:5.0
P1(RMB):490
MW:502.5
One letter sequence:Ac-DEVD-CHO
Molecular Formula:C20H30N4O11
Description:Potent inhibitor for the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC50=0.2 nM). PARP cleavage occurs at the onset of apoptosis. This peptide aldehyde is useful in attenuating apoptotic events in vitro (IC50 = 10 nM).
Literature Reference:D. Wissing et al., Proc. Natl. Acad. Sci. USA, 94, 5973 (1997)
Cas:[184179-08-6]