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CANC-012A
[Lys(Me2)372]-p53 (368-393), p53 K372(Me2), biotin-labeled, human
Biotin-Lys-Gly-Gly-His-Leu-Lys-Ser-Lys(Me2)-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2
Biotin-Lys-Gly-Gly-His-Leu-Lys-Ser-Lys(Me2)-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2
Size：0.25
P1(RMB)：529
MW：3467
One letter sequence：Biotin-KGGHLKS-K(Me2)-KGQSTSRHKKLMFKTEGPDSD-NH2
Molecular Formula：
Description：This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with dimethylation at Lys372 and additional KGW residues on its N-terminus. Methylation at Lys372 activates p53 and induces upregulation of target gene p21. Methylation at Lys372 also inhibits Lys370 methylation by interfering with Smyd2, a lysine methyltransferase, and p53 interaction. Lys 370 methylation reduces p53 transcriptional targets.
Literature Reference：Huang, J. et al. Nature 440, 629 (2006).
Cas：
P1(RMB)：529
MW：3467
One letter sequence：Biotin-KGGHLKS-K(Me2)-KGQSTSRHKKLMFKTEGPDSD-NH2
Molecular Formula：
Description：This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with dimethylation at Lys372 and additional KGW residues on its N-terminus. Methylation at Lys372 activates p53 and induces upregulation of target gene p21. Methylation at Lys372 also inhibits Lys370 methylation by interfering with Smyd2, a lysine methyltransferase, and p53 interaction. Lys 370 methylation reduces p53 transcriptional targets.
Literature Reference：Huang, J. et al. Nature 440, 629 (2006).
Cas：
