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PACA-008A
PACAP-38 (6-38) (human, chicken, mouse, ovine, porcine, rat)
Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2\nTrifluoroacetate salt
Size:0.5
P1(RMB):634
MW:4024.8
One letter sequence:FTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2
Molecular Formula:C182H300N56O45S
Description:This peptide is the fragment 6-38 of PACAP, which is a much more potent and selective inhibitor of PACAP-27-stimulated pituitary adenylate cyclase than PACAP (6-27). Ki values for the inhibition of the enzyme were 7 nM and 150 nM respectively.
Literature Reference:P.Robberecht et al., Mol. Pharmacol., 42, 347 (1992)\nP.Robberecht et al., Eur. J. Biochem., 207, 239 (1992)\nF.Ohno et al., Regul. Peptides, 126, 115 (2005)\nP. Robberecht, P. Gourlet, P. De Neef, M-C. Woussen-Colle, M-C. Vandermeers-Piret,\nA. Vandermeers, and J. Christophe, Eur. J. Biochem., 207, 239 (1992). (Original)\nA. Vandermeers, S. Vandenborre, X. Hou, P. De Neef, P. Robberecht, M-C. Vandermeers-Piret,\nand J. Christophe, Eur. J. Biochem., 208, 815 (1992). (Pharmacol.)
Cas:143748-18-9