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MALA-001B
FRET substrate for lasmepsin
DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS\nTrifluoroacetate salt
Size:5
P1(RMB):4050
MW:1507.78
One letter sequence:ERNleFLSFP
Molecular Formula:C76H98N16O15S
Description:Useful FRET substrate for a continuous fluorescence-based assay of the malaria aspartyl protease (plasmepsin). The peptide sequence ERNleFLSFP is derived from the cleavage site present in hemoglobin, with Nle as a substitution for Met to avoid potential oxidation related problems.
Literature Reference:M.Pennington et al., Innovation and Perspectives in Solid Phase Synthesis &Combinatorial Libraries, 5th International Symposium, London, p. 367, R.Epton, ed., Mayflower Scientific, (1998)\nS.Jiang et al., Antimicrob. Agents Chemother., 45, 2577 (2001)\nM.Stadler et al., J. Antibiot., 58, 775 (2005)
Cas:263718-22-5