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ITLK-002A
IL-8 Inhibitor
Ac-Arg-Arg-Trp-Trp-Cys-Arg-NH2
Size:5
P1(RMB):1090
MW:1003.2
One letter sequence:Ac-RRWWCR-NH2
Molecular Formula:C45H66N18O7S
Description:Antileukinate, Ac-RRWWCR-amide, inhibits the specific binding of 125I-labeled IL-8 to neutrophils with an apparent Ki = 10 μM. The hexapeptide also significantly suppresses neutrophil chemotaxis induced by 10 nM IL-8 at a concentration of 50 μM. The inhibition is specific for IL-8.
Literature Reference:S.Hayashi et al., J. Immunol., 154, 814 (1995)\nY.Fukuno et al., Cytokine, 22, 116 (2003)\nX.Lin et al., Am. J. Physiol. Lung Cell. Mol. Physiol., 289, L583 (2005)\n\n
Cas:138559-60-1