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AMYD-045A
Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg
Arg-Glu(EDANS)-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(DABCYL)-Arg
Size:0.5
P1(RMB):582
MW:2005.2
One letter sequence:R-E(EDANS)-EVNLDAEF-K(DABCYL)-R
Molecular Formula:C91H129N25O25S1
Description:Fluorogenic substrate for pro-memapsin-2 containing the β-secretase site of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 5.4 μM and kcat = 0.24 min-1.
Literature Reference:A.K. Ghosh et al., J. Amer. Chem. Soc., 122, 3522 (2000); J. Ermolieff et al., Biochemistry, 39, 12450 (2000)
Cas:[310427-94-2]