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PARP-015A
(Ala1)-PAR-4 (1-6) amide (mouse)
H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 Trifluoroacetate salt
H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 Trifluoroacetate salt
Size：1mg
P1(RMB)：189
MW：680.8
One letter sequence：AYPGKF-NH2
Molecular Formula：C34H48N8O7
Description：This peptide based on the proteolytically-revealed tethered ligand sequence of the murine proteinase-activated receptor-4 (PAR-4) was shown to cause platelet aggregation with an EC50 value of about 15 µM. PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.
Literature Reference：T.R.Faruqi et al., J. Biol. Chem., 275, 19728 (2000) M.D.Hollenberg and M.Saifeddine, Can. J. Physiol. Pharmacol., 79, 439 (2001) R.A.Henriksen and V.K.Hanks, Arterioscler. Thromb. Vasc. Biol., 22, 861 (2002) Ref: Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003); Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005).
Cas：352017-71-1
P1(RMB)：189
MW：680.8
One letter sequence：AYPGKF-NH2
Molecular Formula：C34H48N8O7
Description：This peptide based on the proteolytically-revealed tethered ligand sequence of the murine proteinase-activated receptor-4 (PAR-4) was shown to cause platelet aggregation with an EC50 value of about 15 µM. PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.
Literature Reference：T.R.Faruqi et al., J. Biol. Chem., 275, 19728 (2000) M.D.Hollenberg and M.Saifeddine, Can. J. Physiol. Pharmacol., 79, 439 (2001) R.A.Henriksen and V.K.Hanks, Arterioscler. Thromb. Vasc. Biol., 22, 861 (2002) Ref: Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003); Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005).
Cas：352017-71-1
