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AMYD-052B
Non-Aβ Component of Alzheimer's Disease Amyloid
Glu-Gln-Val-Thr-Asn-Val-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-Gln-Lys-Thr-Val-Glu-Gly-Ala-Gly-Ser-Ile-Ala-Ala-Ala-Thr-Gly-Phe-Val Trifluoroacetate salt
Size:1mg
P1(RMB):2320
MW:3260.65
One letter sequence:EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFV
Molecular Formula:C141H235N39O49
Description:This peptide was isolated from the insoluble core of Alzheimer's disease (AD) amyloid plaque. It is the fragment (61-95) of NACP or α-synuclein and forms amyloid fibrils via a nucleation-dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases.
Literature Reference:H.Han et al., Chemistry and Biology, 2, 163 (1995) A.Iwai et al., Biochemistry, 34, 10139 (1995
Cas:154040-19-4