中肽生化目录肽版块全新呈现，致力于打造全球最全面的多肽供应平台！我们专业的学术团队将时刻追踪最新最热的研究动向，帮助您发现实际需求，并以最高质量标准提供您所需要的产品。我们将我们将不定期更新产品列表，为您最大限度地节约科研时间，敬请广大客户朋友关注！
AMYD-049B
Amyloid β/A4 Protein Precursor770 (740-770)
Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn Trifluoroacetate salt
Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn Trifluoroacetate salt
Size：5mg
P1(RMB)：3720
MW：3717.12
One letter sequence：AAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Molecular Formula：C162H243N45O52S2
Description：This peptide is the C-terminal fragment of amyloid precursor protein (APP) also known as C31. It is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid β-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid β-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis.
Literature Reference：D.C.Lu et al., Nat. Med., 6, 397 (2000) C.Dumanchin-Njock et al., J. Neurochem., 78, 1153 (2001) V.Galvan et al., J. Neurochem., 82, 283 (2002) Y.Chen et al., J. Cell Biol., 163, 27 (2003) D.C.Lu et al., J. Neurochem., 87, 733 (2003)
Cas：N/A
P1(RMB)：3720
MW：3717.12
One letter sequence：AAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Molecular Formula：C162H243N45O52S2
Description：This peptide is the C-terminal fragment of amyloid precursor protein (APP) also known as C31. It is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid β-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid β-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis.
Literature Reference：D.C.Lu et al., Nat. Med., 6, 397 (2000) C.Dumanchin-Njock et al., J. Neurochem., 78, 1153 (2001) V.Galvan et al., J. Neurochem., 82, 283 (2002) Y.Chen et al., J. Cell Biol., 163, 27 (2003) D.C.Lu et al., J. Neurochem., 87, 733 (2003)
Cas：N/A
