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CASP-089A
Decanoyl-Arg-Val-Lys-Arg-chloromethylketone
Decy-Arg-Val-Lys-Arg-CMK
Decy-Arg-Val-Lys-Arg-CMK
Size：0.5mg
P1(RMB)：551
MW：744.4
One letter sequence：Decy-RVKR-CMK
Molecular Formula：C34H66ClN11O5
Description：Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).
Literature Reference：W.Garten et al., Virology , 172, 25 (1989) A.Stieneke-Gröber et al., EMBO J. , 11, 2407 (1992) S.Hallenberger et al., Nature , 360, 358 (1992) W.Garten et al., Biochimie , 76, 217 (1994) J.-B.Denault et al., FEBS Lett. , 362, 276 (1995) J.-B.Denault et al., J. Cardiovasc. Pharmacol. , 26 (Suppl.3), S47 (1995) S.Hallenberger et al., J. Virol. , 71, 1036 (1997) S.Deb et al., J. Neurosci. Res. , 55, 44 (1999)
Cas：[ 150113-99-8
P1(RMB)：551
MW：744.4
One letter sequence：Decy-RVKR-CMK
Molecular Formula：C34H66ClN11O5
Description：Peptidyl chloromethylketone that binds to the catalytic site of furin and thus inhibits cleavage and fusion activity of viral glycoproteins, as well as virus replication. This compound also decreases the production of b-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Furthermore, other than furin N-1505 the protein also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).
Literature Reference：W.Garten et al., Virology , 172, 25 (1989) A.Stieneke-Gröber et al., EMBO J. , 11, 2407 (1992) S.Hallenberger et al., Nature , 360, 358 (1992) W.Garten et al., Biochimie , 76, 217 (1994) J.-B.Denault et al., FEBS Lett. , 362, 276 (1995) J.-B.Denault et al., J. Cardiovasc. Pharmacol. , 26 (Suppl.3), S47 (1995) S.Hallenberger et al., J. Virol. , 71, 1036 (1997) S.Deb et al., J. Neurosci. Res. , 55, 44 (1999)
Cas：[ 150113-99-8
